HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (1R,2R)-2-(ethoxycarbonyl)cyclopropane-1-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1,2-Diethyl (1R,2R)-1,2-cyclopropanedicarboxylate | HCID 11715303 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (1R,2R)-2-(ethoxycarbonyl)cyclopropane-1-carboxylic acid | HCID 11535603 | — |
Reaction Steps
To a solution of diethyl trans-1,2-cyclopropanedicarboxylate (110 mg, 0.59 mmol) in ethanol (3 mL) is added aqueous 1M NaOH (0.65 mL, 0.65 mmol) and the mixture is stirred at room temperature for 48 hours. To this mixture is added 0.65 mL of aqueous 1M HCl and the solvent is removed under reduced pressure to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08263629B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-290d79fc92454cad88413326bf52206c |
| Source note | uspto-grants-2012_09 |