HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-3-(2-methyl-benzothiazol-6-yl)-acrylic acid methyl ester → 3-(2-Methyl-benzothiazol-6-yl)-propionic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-3-(2-methyl-benzothiazol-6-yl)-acrylic acid methyl ester | HCID 67505787 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-(2-Methyl-benzothiazol-6-yl)-propionic acid methyl ester | HCID 67505695 | — |
Reaction Steps
Next, a solution of (E)-3-(2-methyl-benzothiazol-6-yl)-acrylic acid methyl ester in ethyl acetate (10 mL) is hydrogenated over 10% Pd/C (22 mg, 10% w) at 1 atm for 18 hours. The catalyst is filtered through Celite and the solvent is removed under reduced pressure. The residue is purified by flash chromatography (heptane:EtOAc, 2:1) to give 3-(2-methyl-benzothiazol-6-yl)-propionic acid methyl ester. MS 236.3 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08263629B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-0abafe4433a946d1964d812f0e18dfd6 |
| Source note | uspto-grants-2012_09 |