HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (E)-4-(2-methyl-benzothiazol-6-yl)-but-3-enoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methyl 3-butenoate | HCID 77314 | — |
| Reactant | 6-Iodo-2-methyl-1,3-benzothiazole | HCID 807592 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Product | (E)-4-(2-methyl-benzothiazol-6-yl)-but-3-enoic acid methyl ester | HCID 67505910 | — |
Reaction Conditions
| Temperature | 130 °C |
|---|
Reaction Steps
A mixture of 6-iodo-2-methylbenzo[d]thiazole (275 mg, 1 mmol), but-3-enoic acid methyl ester (100 mg, 1.2 mmol), diacetoxypalladium (22 mg, 0.1 mmol) and triethylamine (304 mg, 3 mmol) MeCN (8 mL) is heated in a microwave apparatus at 130° C. for 30 minutes. The solvent is removed under reduce pressure and the residue is purified by flash chromatography (heptane:EtOAc, 2:1) to give (E)-4-(2-methyl-benzothiazol-6-yl)-but-3-enoic acid methyl ester. MS 248.3 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08263629B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-5c89468b26d342f3b2702dd11e04ef98 |
| Source note | uspto-grants-2012_09 |