Methanol → HCID 59607832, compound

HRID 2384091Notes

Reaction equation

HRID 2384091 reaction equation
[C:1]([CH2:4][C:5]1[O:9][C:8]([C:10]([OH:12])=[O:11])=[CH:7][CH:6]=1)([OH:3])=[O:2].[CH3:13]O>>[CH3:13][O:2][C:1]([CH2:4][C:5]1[O:9][C:8]([C:10]([OH:12])=[O:11])=[CH:7][CH:6]=1)=[O:3]

Participants

3

Reactant 2

HCID 887MethanolHCID 215206745-Carboxyfuran-2-acetic acid

Product 1

HCID 59607832HCID 59607832, compound

Procedure

To a solution of Intermediate 22 (220 mg, 1.29 mmol) in methanol (8 mL) is added Amberlyst-15 resin (50 mg) and the mixture is stirred at room temperature for 18 hrs. The resin is filtered and the solvent is removed under reduced pressure to give the product which is used as is in subsequent reactions. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 3.75 (s, 3H), 3.82 (s, 2H), 6.45 (d, J=3.54 Hz, 1H), 7.29 (d, J=3.54 Hz, 1H), 10.17 (s, broad, 1H).

Workup

  1. filtrationThe resin is filtered
  2. customthe solvent is removed under reduced pressure
  3. customto give the product which

Sources & evidence

ORD record
ord-dc87bb664d334cf7bf82ee946cee02cb
Source dataset
uspto-grants-2012_09
Patent number
US08263629B2

Reaction notes

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