Ethyl 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]acetate → {5-[3,3-Bis-(4-methyl-cyclohexyl)-ureido]-[1,3,4]thiadiazol-2-ylsulfanyl}-acetic acid

Participants

Role	Name	HCID	Charge
Reactant	Ethyl 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]acetate	HCID 351912	—
Reactant	4-methyl-N-(4-methylcyclohexyl)cyclohexan-1-amine	HCID 417228	—
Reactant	{5-[3,3-Bis-(4-methyl-cyclohexyl)-ureido]-[1,3,4]thiadiazol-2-ylsulfanyl}-acetic acid ethyl ester	HCID 66871997	—
Product	{5-[3,3-Bis-(4-methyl-cyclohexyl)-ureido]-[1,3,4]thiadiazol-2-ylsulfanyl}-acetic acid	HCID 57883670	—

Reaction Steps

{5-[3,3-Bis-(4-methyl-cyclohexyl)-ureido]-[1,3,4]thiadiazol-2-ylsulfanyl}-acetic acid ethyl ester prepared from bis-(4-methyl-cyclohexyl)-amine and ethyl-2-[5-amino-1,3,4-thiadiazol-2-yl-thio]acetate as described in general procedures (A) and (B). Hydrolysis using general procedure (F) gave the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08263634B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-2bd09c67432c49d59b8d628f858581cf
Source note	uspto-grants-2012_09