HCID 28423727, compound → HCID 57883467, compound

HRID 2384181Notes

Reaction equation

HRID 2384181 reaction equation
C([O:3][C:4](=[O:29])[CH2:5][S:6][C:7]1[S:11][C:10]([NH:12][C:13]([N:15]([CH:22]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)[CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:14])=[N:9][CH:8]=1)C.C1(NC2CCCCCC2)CCCCC1.NC1SC=NC=1.C(OC(=O)CS)C>>[CH:22]1([N:15]([CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[C:13](=[O:14])[NH:12][C:10]2[S:11][C:7]([S:6][CH2:5][C:4]([OH:29])=[O:3])=[CH:8][N:9]=2)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]1

Participants

4

Reactant 3

HCID 28423727HCID 28423727, compoundHCID 86611193HCID 86611193, compoundHCID 866111945-Aminothiazole 2-mercaptoacetic acid ethyl ester

Product 1

HCID 57883467HCID 57883467, compound

Procedure

[2-(3-Cycloheptyl-3-cyclohexyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid ethyl ester prepared as described in general procedure (A) using cyclohexyl-cycloheptylamine and 5-aminothiazole-2-mercaptoacetic acid ethyl ester. Hydrolysis using general procedure (F) gave the title compound.

Workup

  1. customHydrolysis

Sources & evidence

ORD record
ord-2893b4d74b894d82b7079f0dbc2c0dd2
Source dataset
uspto-grants-2012_09
Patent number
US08263634B2

Reaction notes

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