HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-[3-bromo-5-(trifluoromethyl)phenyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 3-Bromo-5-(trifluoromethyl)aniline | HCID 2735880 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-[3-bromo-5-(trifluoromethyl)phenyl]acetamide | HCID 21959349 | — |
Reaction Steps
3-Bromo-5-(trifluoromethyl)phenylamine (5 g, Alfa-Aesar) was dissolved in AcOH (140 ml) and Ac2O (5.9 ml, Aldrich) was added. The reaction was stirred at RT overnight. The mixture was added slowly to H2O (˜700 ml) forming a white precipitate. The solid was isolated by filtration, washed with H2O and dried under vacuum to yield N-(3-bromo-5-trifluoromethyl-phenyl)-acetamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642624B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-d362e81504494fc290da42d0f1a2643c |
| Source note | uspto-grants-2014_02 |