4-(2-Chloroethyl)morpholine → HCID 86611223, compound

HRID 2384278Notes

Reaction equation

[CH:1]1([N:7]([C@H:19]2[CH2:23][CH2:22][N:21]([C:24](=[O:26])[CH3:25])[CH2:20]2)[C:8]([NH:10][C:11]2[S:12][C:13]([S:16]C#N)=[CH:14][N:15]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.SC[C@@H]([C@@H](CS)O)O.Cl[CH2:36][CH2:37][N:38]1[CH2:43][CH2:42][O:41][CH2:40][CH2:39]1>>[C:24]([N:21]1[CH2:22][CH2:23][C@H:19]([N:7]([CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[C:8]([NH:10][C:11]2[S:12][C:13]([S:16][CH2:36][CH2:37][N:38]3[CH2:43][CH2:42][O:41][CH2:40][CH2:39]3)=[CH:14][N:15]=2)=[O:9])[CH2:20]1)(=[O:26])[CH3:25]

Participants

Reactant 3

HCID 767274-(2-Chloroethyl)morpholine

HCID 439352Dithioerythritol

HCID 86611224HCID 86611224, compound

Product 1

HCID 86611223HCID 86611223, compound

Procedure

Prepared as described in general procedure (H) using 1-cyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-1-[1-(acetyl)-pyrrolidin-3(S)-yl]-urea, dithioerythritol and N-(2-chloroethyl)morpholine

Workup

customPrepared

Sources & evidence

ORD record: ord-b57d0854435149e59d27d48755978c97
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08263634B2

Reaction notes

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