1-(2-Chloroethyl)pyrrolidine → HCID 178461383, compound

HRID 2384288Notes

Reaction equation

HRID 2384288 reaction equation
[CH:1]1([N:7]([C@H:19]2[CH2:24][CH2:23][C@H:22]([CH3:25])[CH2:21][CH2:20]2)[C:8]([NH:10][C:11]2[S:12][C:13]([S:16]C#N)=[CH:14][N:15]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.SC[C@@H]([C@@H](CS)O)O.Cl[CH2:35][CH2:36][N:37]1[CH2:41][CH2:40][CH2:39][CH2:38]1>>[CH:1]1([N:7]([C@H:19]2[CH2:20][CH2:21][C@H:22]([CH3:25])[CH2:23][CH2:24]2)[C:8]([NH:10][C:11]2[S:12][C:13]([S:16][CH2:35][CH2:36][N:37]3[CH2:41][CH2:40][CH2:39][CH2:38]3)=[CH:14][N:15]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 816691-(2-Chloroethyl)pyrrolidineHCID 439352DithioerythritolHCID 178461390HCID 178461390, compound

Product 1

HCID 178461383HCID 178461383, compound

Procedure

Prepared as described in general procedure (H) using 1-cyclohexyl-1-(trans-4-methyl-cyclohexyl)-3-(5-thiocyanato-thiazol-2-yl)-urea, dithioerythritol and N-(2-chloroethyl)pyrrolidine

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-96718b59dddd49619fdb49ef1361b31a
Source dataset
uspto-grants-2012_09
Patent number
US08263634B2

Reaction notes

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