Tributyl phosphite → Ethyl 2-dibutoxyphosphorylacetate

Participants

Reaction Conditions

Reaction Steps

100 parts by weight of tributyl phosphite and 66 parts by weight of ethyl bromoacetate were put into a reactor equipped with a distillation tube, and the inside of the reactor was substituted by nitrogen. Subsequently, the reactor was heated at 120° C. to start a reaction. Since bromobutane as a by-product began to distill out immediately, the reaction was maintained until the distillation-out of bromoethane slowed down. When the distillation-out of bromoethane became moderate, the reactor was further heated at 170° C. to continue the reaction for 3 hours. The reaction mixture was distilled at 180° C. under a reduced pressure to obtain an achromatic transparent liquid (yield of 88%, boiling point of 249° C./760 mmHg).

Provenance & Evidence