3,5-Di-tert-butylaniline → N-{3,5-Bis[(1,1-dimethyl)ethyl]phenyl}-5-chloro-2-hydroxynicotinamide

HRID 2384325Notes

Reaction equation

HRID 2384325 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[CH3:12][C:13]([C:16]1[CH:17]=[C:18]([CH:20]=[C:21]([C:23]([CH3:26])([CH3:25])[CH3:24])[CH:22]=1)[NH2:19])([CH3:15])[CH3:14]>>[CH3:15][C:13]([C:16]1[CH:17]=[C:18]([NH:19][C:7](=[O:9])[C:6]2[CH:10]=[C:2]([Cl:1])[CH:3]=[N:4][C:5]=2[OH:11])[CH:20]=[C:21]([C:23]([CH3:26])([CH3:25])[CH3:24])[CH:22]=1)([CH3:12])[CH3:14]

Participants

3

Reactant 2

HCID 754193,5-Di-tert-butylanilineHCID 178524411HCID 178524411, compound

Product 1

HCID 178441164N-{3,5-Bis[(1,1-dimethyl)ethyl]phenyl}-5-chloro-2-hydroxynicotinamideYield 59.1%

Procedure

Using 5-chloro-2-hydroxynicotinic acid and 3,5-bis[(1,1-dimethyl)ethyl]aniline as the raw materials, the same operation as the example 24 gave the title compound.

Sources & evidence

ORD record
ord-fbd0f9397a144e70b8cb792fc2e98f5c
Source dataset
uspto-grants-2012_09
Patent number
US08263657B2

Reaction notes

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