3-(3-(Piperidin-1-yl)propyl)-5-(trifluoromethyl)benzenamine → 3-(1-Methylpiperidin-4-yl)-5-(trifluoromethyl)aniline

HRID 238433Notes

Reaction equation

HRID 238433 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[CH:9]=[C:10]([NH:18]C(=O)C)[CH:11]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:13]=2)[CH2:4][CH2:3]1.N1(CCCC2C=C(N)C=C(C(F)(F)F)C=2)CCCCC1>>[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([C:8]2[CH:9]=[C:10]([NH2:18])[CH:11]=[C:12]([C:14]([F:15])([F:16])[F:17])[CH:13]=2)[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 219595273-(3-(Piperidin-1-yl)propyl)-5-(trifluoromethyl)benzenamineHCID 21959571N-[3-(1-Methylpiperidin-4-yl)-5-trifluoromethyl-phenyl]-acetamide

Product 1

HCID 219593793-(1-Methylpiperidin-4-yl)-5-(trifluoromethyl)aniline

Procedure

3-(1-Methylpiperidin-4-yl)-5-trifluoromethyl-phenylamine was prepared from N-[3-(1-methylpiperidin-4-yl)-5-trifluoromethyl-phenyl]-acetamide similar to the procedure described in the preparation of 3-(3-piperidin-1-yl-propyl)-5-trifluoromethyl-phenylamine.

Sources & evidence

ORD record
ord-533463de294e405b8c3bf4b0caf89e29
Source dataset
uspto-grants-2014_02
Patent number
US08642624B2

Reaction notes

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