Benzenamine, 3,5-bis(trifluoromethyl)- → N-[3,5-Bis(trifluoromethyl)phenyl]-5-cyano-2-hydroxybenzamide

HRID 2384346Notes

Reaction equation

HRID 2384346 reaction equation
[C:1]([C:3]1[CH:11]=[C:7]([C:8]([OH:10])=O)[C:6]([OH:12])=[CH:5][CH:4]=1)#[N:2].[F:13][C:14]([F:27])([F:26])[C:15]1[CH:16]=[C:17]([CH:19]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:21]=1)[NH2:18]>>[F:13][C:14]([F:26])([F:27])[C:15]1[CH:16]=[C:17]([NH:18][C:8](=[O:10])[C:7]2[CH:11]=[C:3]([C:1]#[N:2])[CH:4]=[CH:5][C:6]=2[OH:12])[CH:19]=[C:20]([C:22]([F:23])([F:25])[F:24])[CH:21]=1

Participants

3

Reactant 2

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-HCID 130269355-Cyano-2-hydroxybenzoic acid

Product 1

HCID 9976653N-[3,5-Bis(trifluoromethyl)phenyl]-5-cyano-2-hydroxybenzamideYield 16.6%

Procedure

Using 5-cyanosalicylic acid and 3,5-bis(trifluoromethyl)aniline as the raw materials, the same operation as the example 16 gave the title compound.

Sources & evidence

ORD record
ord-d923220e7a2e4b5f8322af4487d5ae43
Source dataset
uspto-grants-2012_09
Patent number
US08263657B2

Reaction notes

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