5-Bromosalicylic acid → HCID 10320418, compound

HRID 2384417Notes

Reaction equation

HRID 2384417 reaction equation
[Br:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[N:12]1([C:17]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][C:18]=2[NH2:19])[CH2:16][CH2:15][CH2:14][CH2:13]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:19][C:18]1[CH:20]=[C:21]([C:24]([F:25])([F:26])[F:27])[CH:22]=[CH:23][C:17]=1[N:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:9]

Participants

3

Reactant 2

HCID 69725-Bromosalicylic acidHCID 5187512-(Pyrrolidin-1-yl)-5-(trifluoromethyl)aniline

Product 1

HCID 10320418HCID 10320418, compoundYield 44.5%

Procedure

Using 5-bromosalicylic acid and 2-(1-pyrrolidinyl)-5-(trifluoromethyl)aniline as the raw materials, the same operation as the example 16 gave the title compound.

Sources & evidence

ORD record
ord-61daa53f062f4699b4882252d472fd54
Source dataset
uspto-grants-2012_09
Patent number
US08263657B2

Reaction notes

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