Aniline → 5-Bromosalicylanilide

HRID 2384429Notes

Reaction equation

[Br:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[NH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:9]

Participants

Reactant 2

HCID 6115Aniline

HCID 69725-Bromosalicylic acid

Product 1

HCID 1240745-BromosalicylanilideYield 68.8%

Procedure

Using 5-bromosalicylic acid and aniline as the raw materials, the same operation as the example 16 gave the title compound.

Sources & evidence

ORD record: ord-7d4db9923dc546349c049fa8d5603973
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08263657B2

Reaction notes

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