Hexane → 5-Bromo-4-tert-butyl-1,3-thiazol-2-amine

HRID 2384470Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2384470
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[N:6]=1.[Br:11]N1C(=O)CCC1=O.CCCCCC>C(Cl)(Cl)(Cl)Cl>[NH2:1][C:2]1[S:3][C:4]([Br:11])=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[N:6]=1

Komponenten

5

Edukt 3

HCID 8058HexaneHCID 67184N-bromobutanimideHCID 27342024-tert-Butyl-1,3-thiazol-2-amine

Produkt 1

HCID 7291355-Bromo-4-tert-butyl-1,3-thiazol-2-amineAusbeute 93,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

2-Amino-4-[(1,1-dimethyl)ethyl]thiazole (0.87 g, 5.6 mmol) was dissolved in carbon tetrachloride (9 mL). N-Bromosuccinimide (1.00 g, 5.6 mmol) was added, and the mixture was stirred at room temperature for 1 hour. Hexane was added to the reaction mixture, the insoluble matter was filtered off, and the residue obtained by evaporation of the filtrate under reduced pressure was purified by chromatography on silica gel (hexane:ethyl acetate=2:1) to give the title compound (1.23 g, 93.7%) as a yellowish gray powder.

Aufarbeitung

  1. filtrationthe insoluble matter was filtered off
  2. customthe residue obtained by evaporation of the filtrate under reduced pressure
  3. customwas purified by chromatography on silica gel (hexane:ethyl acetate=2:1)

Quellen und Nachweise

ORD-Eintrag
ord-1c8e0055749d486a96b5d9abd4fbb6f4
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08263657B2

Notizen zur Reaktion

Wird geladen…