5-Bromosalicylic acid → 5-bromo-2-hydroxy-N-(4-phenyl-1,3-thiazol-2-yl)benzamide

HRID 2384472Notes

Reaction equation

HRID 2384472 reaction equation
[Br:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[NH2:12][C:13]1[S:14][CH:15]=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:17]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:12][C:13]1[S:14][CH:15]=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:17]=1)=[O:9]

Participants

3

Reactant 2

HCID 69725-Bromosalicylic acidHCID 403022-Amino-4-phenylthiazole

Product 1

HCID 11863795-bromo-2-hydroxy-N-(4-phenyl-1,3-thiazol-2-yl)benzamideYield 16%

Procedure

Using 5-bromosalicylic acid and 2-amino-4-phenylthiazole as the raw materials, the same operation as the example 195(3) gave the title compound.

Sources & evidence

ORD record
ord-333f06c172394d398c0492cd0e9e6d69
Source dataset
uspto-grants-2012_09
Patent number
US08263657B2

Reaction notes

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