5-Bromosalicylic acid → HCID 17860274, compound

HRID 2384476Notes

Reaction equation

HRID 2384476 reaction equation
[Br:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[NH2:12][C:13]1[S:14][C:15]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[C:16]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[N:17]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:12][C:13]1[S:14][C:15]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[C:16]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[N:17]=1)=[O:9]

Participants

3

Reactant 2

HCID 69725-Bromosalicylic acidHCID 178603104-benzyl-5-phenylthiazol-2-amine

Product 1

HCID 17860274HCID 17860274, compound

Procedure

Using 5-bromosalicylic acid and 2-amino-4-benzyl-5-phenylthiazole as the raw materials, the same operation as the example 195(3) gave the title compound. (2-Amino-4-benzyl-5-phenylthiazole: refer to Chem. Pharm. Bull., 1962, 10, 376.)

Sources & evidence

ORD record
ord-3674803a6ac04ef3acac068b27358b8c
Source dataset
uspto-grants-2012_09
Patent number
US08263657B2

Reaction notes

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