5-Bromosalicylic acid → 5-Bromo-N-[5-phenyl-4-(trifluoromethyl)thiazol-2-yl]-2-hydroxybenzamide

HRID 2384477Notes

Reaction equation

HRID 2384477 reaction equation
[Br:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[NH2:12][C:13]1[S:14][C:15]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[C:16]([C:18]([F:21])([F:20])[F:19])[N:17]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:12][C:13]1[S:14][C:15]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)=[C:16]([C:18]([F:21])([F:19])[F:20])[N:17]=1)=[O:9]

Participants

3

Reactant 2

HCID 69725-Bromosalicylic acidHCID 51855352-Amino-5-phenyl-4-(trifluoromethyl)thiazole

Product 1

HCID 865955415-Bromo-N-[5-phenyl-4-(trifluoromethyl)thiazol-2-yl]-2-hydroxybenzamideYield 33.2%

Procedure

Using 5-bromosalicylic acid and 2-amino-5-phenyl-4-(trifluoromethyl)thiazole as the raw materials, the same operation as the example 195(3) gave the title compound.

Sources & evidence

ORD record
ord-c01822eb31954abda35666f2ad53b808
Source dataset
uspto-grants-2012_09
Patent number
US08263657B2

Reaction notes

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