4-Toluenesulfonyl chloride → HCID 69809888, compound

Participants

Reaction Conditions

Reaction Steps

N-(2-hydroxyethyl)quinoline-2-carboxamide was dissolved in DCE (40 mL) in an oven dried 100 mL pear bottomed flask. To a 250 mL 3 necked round bottomed flask was fitted a water condenser, and a magnetic stir bar was added. p-Toluene sulfonyl chloride (2.2288 g, 11.65 mmol) and N,N-dimethylaminopyridine (95.4 mg, 0.78 mmol) were added to the reaction flask. The flask was placed under N2 atmosphere. DCE (30 mL) was added to the reaction flask and cooled to −5° C. The reaction flask was charged with triethylamine (5.50 mL, 39 mmol). The reaction mixture was stirred for 10 min and allowed react according to the formula

Provenance & Evidence