HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-3-chloropropane → (1S,5R)-3-(3-chloropropyl)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-3-chloropropane | HCID 8006 | — |
| Reactant | (1S,5R)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane | HCID 59346768 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Diisopropylethylamine | HCID 81531 | — |
| Product | (1S,5R)-3-(3-chloropropyl)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane | HCID 59346766 | — |
Reaction Steps
To a solution of (1S,5R)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane (300 mg) in dry tetrahydrofuran (3 mL), diisopropylethylamine (0.65 mL) and 1-bromo-3-chloropropane (1.01 mL) were added and the resulting mixture was refluxed for 3 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08263782B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-b567dc8eade44c7daead1327d0ee30de |
| Source note | uspto-grants-2012_09 |