HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine Oxide → 2-Chloro-4-fluoro-5-nitrobenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine Oxide | HCID 13097 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Chloro-4-fluoro-5-nitrobenzoic Acid | HCID 7210828 | — |
| Product | 2-Chloro-4-fluoro-5-nitrobenzoyl chloride | HCID 15124384 | — |
Reaction Steps
22.3 g (0.1 mol) of 2-chloro-4-fluoro-5-nitrobenzoic acid 16.8 g (0.14 mol) of thionyl chloride 0.1 g (0.00036 mol) of triphenyl phosphine oxide Yield*: 46.5 g (>99% of theory) of the title compound as a solution in chlorobenzene * In these examples, the yield was determined by means of 19F-NMR with internal standard. Fluoride value: 0.01 g/l
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08263806B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-7156f29c93134224b24fc0e863dd64e4 |
| Source note | uspto-grants-2012_09 |