1-Acetylpiperazine → HCID 67240455, compound

HRID 2384604Notes

Reaction equation

[F:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20](SC)=[N:19][C:18]4=[O:24])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:27]([F:30])([F:29])[F:28])[CH:3]=1.[N:31]1([C:37](=[O:39])[CH3:38])[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1>>[C:37]([N:31]1[CH2:36][CH2:35][N:34]([C:20]2[S:21][C:17](=[CH:16][C:12]3[CH:11]=[C:10]4[C:15](=[CH:14][CH:13]=3)[N:7]([CH2:6][C:5]3[CH:25]=[CH:26][C:2]([F:1])=[CH:3][C:4]=3[C:27]([F:30])([F:29])[F:28])[N:8]=[CH:9]4)[C:18](=[O:24])[N:19]=2)[CH2:33][CH2:32]1)(=[O:39])[CH3:38]

Participants

Reactant 2

HCID 837951-Acetylpiperazine

HCID 67242511HCID 67242511, compound

Product 1

HCID 67240455HCID 67240455, compound

Procedure

2-(4-Acetyl-piperazin-1-yl)-5-[1-(4-fluoro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-thiazol-4-one was prepared from 5-[1-(4-fluoro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazol-4-one and 1-piperazin-1-yl-ethanone following General Procedure C.

Sources & evidence

ORD record: ord-06dfd3db3274481e85a8c71ce4994dd6
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08263781B2

Reaction notes

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