Methyl iodide → 5-[1-(4-Methanesulfonyl-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazol-4-one

HRID 2384618Notes

Reaction equation

[CH3:1][S:2]([C:5]1[CH:28]=[CH:27][C:8]([CH2:9][N:10]2[C:18]3[C:13](=[CH:14][C:15]([CH:19]=[C:20]4[S:24][C:23](=[S:25])[NH:22][C:21]4=[O:26])=[CH:16][CH:17]=3)[CH:12]=[N:11]2)=[C:7]([C:29]([F:32])([F:31])[F:30])[CH:6]=1)(=[O:4])=[O:3].[CH3:33]I>>[CH3:1][S:2]([C:5]1[CH:28]=[CH:27][C:8]([CH2:9][N:10]2[C:18]3[C:13](=[CH:14][C:15]([CH:19]=[C:20]4[S:24][C:23]([S:25][CH3:33])=[N:22][C:21]4=[O:26])=[CH:16][CH:17]=3)[CH:12]=[N:11]2)=[C:7]([C:29]([F:32])([F:31])[F:30])[CH:6]=1)(=[O:4])=[O:3]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 866545515-[1-(4-Methanesulfonyl-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-thioxo-thiazolidin-4-one

Product 1

HCID 672399595-[1-(4-Methanesulfonyl-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazol-4-one

Procedure

5-[1-(4-Methanesulfonyl-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazol-4-one was prepared from 5-[1-(4-Methanesulfonyl-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-thioxo-thiazolidin-4-one and methyl iodide following General Procedure C.

Sources & evidence

ORD record: ord-ef5dbe6635554186a30b5f4efae2f4d0
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08263781B2

Reaction notes

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