Piperazin-2-one → HCID 67241513, compound

HRID 2384622Notes

Reaction equation

HRID 2384622 reaction equation
[Cl:1][C:2]1[CH:26]=[C:25]([S:27]([CH3:30])(=[O:29])=[O:28])[CH:24]=[CH:23][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([CH:14]=[C:15]3[S:19][C:18](SC)=[N:17][C:16]3=[O:22])=[CH:11][CH:12]=2)[CH:7]=[N:6]1.[NH:31]1[CH2:36][CH2:35][NH:34][CH2:33][C:32]1=[O:37]>>[Cl:1][C:2]1[CH:26]=[C:25]([S:27]([CH3:30])(=[O:28])=[O:29])[CH:24]=[CH:23][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([CH:14]=[C:15]3[S:19][C:18]([N:34]4[CH2:35][CH2:36][NH:31][C:32](=[O:37])[CH2:33]4)=[N:17][C:16]3=[O:22])=[CH:11][CH:12]=2)[CH:7]=[N:6]1

Participants

3

Reactant 2

HCID 231360Piperazin-2-oneHCID 67240676HCID 67240676, compound

Product 1

HCID 67241513HCID 67241513, compound

Procedure

4-{5-[1-(2-Chloro-4-methanesulfonyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-piperazin-2-one was prepared from 5-[1-(2-chloro-4-methanesulfonyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazol-4-one and piperazin-2-one following General Procedure C.

Sources & evidence

ORD record
ord-6560098b4b5f4ef49917cee0a579dbfb
Source dataset
uspto-grants-2012_09
Patent number
US08263781B2

Reaction notes

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