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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2384672Generated: October 25, 2026

1-(2-Ethoxyethyl)piperazine → 5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[4-(2-ethoxy-ethyl)-piperazin-1-yl]-thiazol-4-one

https://huagongshe.com/reaction/2384672

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Ethoxyethyl)piperazineHCID 2734643—
Reactant5-[1-(2,4-bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]2-methylsulfanyl-thiazol-4-oneHCID 86654543—
Product5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[4-(2-ethoxy-ethyl)-piperazin-1-yl]-thiazol-4-oneHCID 86654569—

Reaction Steps

5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[4-(2-ethoxy-ethyl)-piperazin-1-yl]-thiazol-4-one was prepared from 5-[1-(2,4-bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazol-4-one and 1-(2-ethoxy-ethyl)-piperazine following General Procedure C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08263781B2
Source datasetuspto-grants-2012_09
ORD IDord-b165b5c473e34e16bc33a3f8c471a48f
Source noteuspto-grants-2012_09