3-azetidinecarboxylic Acid → HCID 86654575, compound

HRID 2384689Notes

Reaction equation

HRID 2384689 reaction equation
[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20](SC)=[N:19][C:18]4=[O:24])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([CH:27]2[CH2:29][CH2:28]2)[CH:3]=1.[NH:30]1[CH2:33][CH:32]([C:34]([OH:36])=[O:35])[CH2:31]1>>[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][CH:20]([N:30]5[CH2:33][CH:32]([C:34]([OH:36])=[O:35])[CH2:31]5)[NH:19][C:18]4=[O:24])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([CH:27]2[CH2:28][CH2:29]2)[CH:3]=1

Participants

3

Reactant 2

HCID 931923-azetidinecarboxylic AcidHCID 67241013HCID 67241013, compound

Product 1

HCID 86654575HCID 86654575, compound

Procedure

1-(5-[1-(4-Chloro-2-cyclopropyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-dihydro-thiazol-2-yl]-azetidine-3-carboxylic acid was prepared from 5-[1-(4-chloro-2-cyclopropyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazol-4-one and azetidine-3-carboxylic acid following General Procedure C.

Sources & evidence

ORD record
ord-a46bd5ed802e4c1c91a31de2c548f419
Source dataset
uspto-grants-2012_09
Patent number
US08263781B2

Reaction notes

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