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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2384697Generated: October 30, 2026

tert-Butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate → HCID 86654578, compound

https://huagongshe.com/reaction/2384697

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylateHCID 24820286—
Reactant5-[1-(2,4-bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]2-methylsulfanyl-thiazol-4-oneHCID 86654543—
ProductHCID 86654578HCID 86654578—

Reaction Steps

4-{5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-3-hydroxymethyl-piperazine-1-carboxylic acid tert-butyl ester was prepared from 5-[1-(2,4-bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazol-4-one and 3-(R)-hydroxymethyl-piperazine-1-carboxylic acid tert-butyl ester following General Procedure C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08263781B2
Source datasetuspto-grants-2012_09
ORD IDord-b8d0d87d4ebc4afd9c5fe559b82062d3
Source noteuspto-grants-2012_09