HCID 178418361, compound → HCID 178420016, compound

HRID 2384702Notes

Reaction equation

HRID 2384702 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([C:17]2[NH:21][N:20]=[N:19][N:18]=2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1.[H][H]>[Pd].C(O)C>[NH:21]1[C:17]([CH:14]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)=[N:18][N:19]=[N:20]1

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178525126HCID 178525126, compound

Product 1

HCID 178420016HCID 178420016, compoundYield 94.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 4-(1H-Tetrazol-5-yl)-piperidine-1-carboxylic acid benzyl ester (0.6 g, 2.08 mmol) and activated 10 wt. % palladium on carbon (0.065 g) in ethanol (35 mL) was stirred vigorously under 1 atmosphere hydrogen atmosphere for 4 hours. The reaction mixture was then filtered through a microglass filter paper and the solid washed abundantly with methanol and water. The solvent was evaporated in vacuo to yield the 4-(1H-tetrazol-5-yl)-piperidine as a white solid (0.30 g, 94%).

Workup

  1. filtrationThe reaction mixture was then filtered through a microglass
  2. filtrationfilter paper
  3. washthe solid washed abundantly with methanol and water
  4. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-4de235c1c49a441a9d9a18a6d22af7c7
Source dataset
uspto-grants-2012_09
Patent number
US08263781B2

Reaction notes

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