HCID 67241207, compound → HCID 86654584, compound

HRID 2384753Notes

Reaction equation

HRID 2384753 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=O)=[CH:12][CH:13]=2)[CH:8]=[N:7]1.[OH:27][CH2:28][C@@H:29]1[O:34][CH2:33][CH2:32][N:31]([C:35]2[S:36][CH2:37][C:38](=[O:40])[N:39]=2)[CH2:30]1>>[F:26][C:2]([F:1])([F:25])[C:3]1[CH:20]=[C:19]([C:21]([F:22])([F:23])[F:24])[CH:18]=[CH:17][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=[C:37]3[S:36][C:35]([N:31]4[CH2:32][CH2:33][O:34][C@@H:29]([CH2:28][OH:27])[CH2:30]4)=[N:39][C:38]3=[O:40])=[CH:12][CH:13]=2)[CH:8]=[N:7]1

Participants

3

Reactant 2

HCID 67241207HCID 67241207, compoundHCID 866545381-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde

Product 1

HCID 86654584HCID 86654584, compound

Procedure

5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2(R)-(2-hydroxymethyl-morpholin-4-yl)-thiazol-4-one was prepared from 1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde and 2(R)-(2-Hydroxymethyl-morpholin-4-yl)-thiazol-4-one following General Procedure D.

Sources & evidence

ORD record
ord-1d9cfc2739e449098a20d08fa5d142ba
Source dataset
uspto-grants-2012_09
Patent number
US08263781B2

Reaction notes

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