HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Piperidinecarboxylic acid → 1-(4-Oxo-4,5-dihydro-thiazol-2-yl)piperidine-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Piperidinecarboxylic acid | HCID 3773 | — |
| Reactant | 2-(Methylsulfanyl)-4,5-dihydro-1,3-thiazol-4-one | HCID 1482022 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(4-Oxo-4,5-dihydro-thiazol-2-yl)piperidine-4-carboxylic acid | HCID 67240640 | — |
Reaction Steps
To a solution of 2-methylsulfanyl-thiazol-4-one (4.4 g, 30 mmol) in MeOH (60 mL) was added piperidine-4-carboxylic acid (3.9 g, 30 mmol). The mixture was stirred at room temperature for 16 hours. The resulting solid was collected by filtration, washed with fresh MeOH and dried to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08263781B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-aa3edc77b75a4dea9a759f48546da926 |
| Source note | uspto-grants-2012_09 |