HRID2384755

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C1CSC(N2CCC(C(=O)NS(=O)(=O)N3CCCC3)CC2)=N1

HCID67241120

未命名化合物

结构：O=Cc1ccc2c(cnn2Cc2ccc(C(F)(F)F)cc2C(F)(F)F)c1

HCID86654538

未命名化合物

PRODUCTS

生成物

结构：O=C1N=C(N2CCC(C(=O)NS(=O)(=O)N3CCCC3)CC2)SC1=Cc1ccc2c(cnn2Cc2ccc(C(F)(F)F)cc2C(F)(F)F)c1

HCID76756302

未命名化合物

PROCEDURE

实验过程

Pyrrolidine-1-sulfonic acid (1-{5-[1-(2,4-bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-piperidine-4-carbonyl)-amide was prepared from 1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde and Pyrrolidine-1-sulfonic acid [1-(4-oxo-4,5-dihydro-thiazol-2-yl)-piperidine-4-carbonyl]-amide following General Procedure E.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7ee2d3a40b8a4812917a84132906ecda
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08263781B2
来源说明: uspto-grants-2012_09

反应 SMILES

[F:1][C:2]([F:26])([F:25])[C:3]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=O)=[CH:12][CH:13]=2)[CH:8]=[N:7]1.[O:27]=[C:28]1[CH2:32][S:31][C:30]([N:33]2[CH2:38][CH2:37][CH:36]([C:39]([NH:41][S:42]([N:45]3[CH2:49][CH2:48][CH2:47][CH2:46]3)(=[O:44])=[O:43])=[O:40])[CH2:35][CH2:34]2)=[N:29]1>>[F:26][C:2]([F:1])([F:25])[C:3]1[CH:20]=[C:19]([C:21]([F:22])([F:23])[F:24])[CH:18]=[CH:17][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=[C:32]3[S:31][C:30]([N:33]4[CH2:34][CH2:35][CH:36]([C:39]([NH:41][S:42]([N:45]5[CH2:49][CH2:48][CH2:47][CH2:46]5)(=[O:44])=[O:43])=[O:40])[CH2:37][CH2:38]4)=[N:29][C:28]3=[O:27])=[CH:12][CH:13]=2)[CH:8]=[N:7]1