2(S)-(2-Hydroxymethyl-morpholin-4-yl)-thiazol-4-one → 5-[1-(2,4-Bis-trifluoromethyl-benzyl)-3-chloro-1H-indazol-5-ylmethylene]-2-(2-(S)-hydroxymethyl-morpholin-4-yl)-thiazol-4-one

HRID 2384773Notes

Reaction equation

HRID 2384773 reaction equation
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[CH:18][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=O)=[CH:12][CH:13]=2)[C:8]([Cl:17])=[N:7]1.[OH:28][CH2:29][C@H:30]1[O:35][CH2:34][CH2:33][N:32]([C:36]2[S:37][CH2:38][C:39](=[O:41])[N:40]=2)[CH2:31]1>>[F:27][C:2]([F:1])([F:26])[C:3]1[CH:21]=[C:20]([C:22]([F:23])([F:25])[F:24])[CH:19]=[CH:18][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=[C:38]3[S:37][C:36]([N:32]4[CH2:33][CH2:34][O:35][C@H:30]([CH2:29][OH:28])[CH2:31]4)=[N:40][C:39]3=[O:41])=[CH:12][CH:13]=2)[C:8]([Cl:17])=[N:7]1

Participants

3

Reactant 2

HCID 672406872(S)-(2-Hydroxymethyl-morpholin-4-yl)-thiazol-4-oneHCID 866545931-(2,4-Bis-trifluoromethyl-benzyl)-3-chloro-1H-indazole-5-carbaldehyde

Product 1

HCID 866545945-[1-(2,4-Bis-trifluoromethyl-benzyl)-3-chloro-1H-indazol-5-ylmethylene]-2-(2-(S)-hydroxymethyl-morpholin-4-yl)-thiazol-4-one

Procedure

5-[1-(2,4-Bis-trifluoromethyl-benzyl)-3-chloro-1H-indazol-5-ylmethylene]-2-(2-(S)-hydroxymethyl-morpholin-4-yl)-thiazol-4-one was prepared from 1-(2,4-Bis-trifluoromethyl-benzyl)-3-chloro-1H-indazole-5-carbaldehyde and 2-(2-(S)—Hydroxymethyl-morpholin-4-yl)-thiazol-4-one following general procedure D.

Sources & evidence

ORD record
ord-1c2760c1bb43433ba528931cddfbd885
Source dataset
uspto-grants-2012_09
Patent number
US08263781B2

Reaction notes

Loading…