2(S)-(2-Hydroxymethyl-morpholin-4-yl)-thiazol-4-one → 5-[3-Chloro-1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-(2-hydroxymethyl-morpholin-4-yl)-thiazol-4-one

HRID 2384775Notes

Reaction equation

HRID 2384775 reaction equation
[Cl:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH:11]=O)[CH:9]=2)[N:4]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[C:21]([F:24])([F:23])[F:22])[N:3]=1.[OH:25][CH2:26][C@H:27]1[O:32][CH2:31][CH2:30][N:29]([C:33]2[S:34][CH2:35][C:36](=[O:38])[N:37]=2)[CH2:28]1>>[Cl:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH:11]=[C:35]3[S:34][C:33]([N:29]4[CH2:30][CH2:31][O:32][CH:27]([CH2:26][OH:25])[CH2:28]4)=[N:37][C:36]3=[O:38])[CH:9]=2)[N:4]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[C:21]([F:22])([F:23])[F:24])[N:3]=1

Participants

3

Reactant 2

HCID 672406872(S)-(2-Hydroxymethyl-morpholin-4-yl)-thiazol-4-oneHCID 866545953-Chloro-1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde

Product 1

HCID 672405485-[3-Chloro-1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-(2-hydroxymethyl-morpholin-4-yl)-thiazol-4-one

Procedure

5-[3-Chloro-1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-(2-hydroxymethyl-morpholin-4-yl)-thiazol-4-one was prepared from 3-Chloro-1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde and 2-(2-(S)—Hydroxymethyl-morpholin-4-yl)-thiazol-4-one following general procedure D.

Sources & evidence

ORD record
ord-984f1f26b71742ee8b6b65b3a986a037
Source dataset
uspto-grants-2012_09
Patent number
US08263781B2

Reaction notes

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