Iodine → HCID 178519380, compound

Participants

Reaction Steps

To a solution of 1H-indazole-5-carboxaldehyde (670.2 mg, 4.59 mmol) in DMF (5 mL) were added iodine (2.33 g, 9.17 mmol) and potassium hydroxide pellets (1.03 g, 18.36 mmol) at room temperature under stirring. After 4 h, the mixture was quenched with aqueous Na2S2O3 solution and extracted with EtOAc. The combined extracts were washed with brine, dried, and evaporated to afford the title product.

Provenance & Evidence