4-Piperidinecarboxylic acid → HCID 86654598, compound

HRID 2384783Notes

Reaction equation

HRID 2384783 reaction equation
[F:1][C:2]([F:35])([F:34])[C:3]1[CH:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[CH:26][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=[C:16]3[S:20][C:19](SCC)=[N:18][C:17]3=[O:24])=[CH:12][CH:13]=2)[C:8]([I:25])=[N:7]1.[NH:36]1[CH2:41][CH2:40][CH:39]([C:42]([OH:44])=[O:43])[CH2:38][CH2:37]1>>[F:1][C:2]([F:34])([F:35])[C:3]1[CH:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[CH:26][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=[C:16]3[S:20][C:19]([N:36]4[CH2:41][CH2:40][CH:39]([C:42]([OH:44])=[O:43])[CH2:38][CH2:37]4)=[N:18][C:17]3=[O:24])=[CH:12][CH:13]=2)[C:8]([I:25])=[N:7]1

Participants

3

Reactant 2

HCID 37734-Piperidinecarboxylic acidHCID 86654599HCID 86654599, compound

Product 1

HCID 86654598HCID 86654598, compound

Procedure

1-[5-({1-[2,4-Bis(trifluoromethyl)benzyl]-3-iodo-1H-indazol-5-yl}methylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxylic acid was prepared from 5-[1-(2,4-Bis-trifluoromethyl-benzyl)-3-iodo-1H-indazol-5-ylmethylene]-2-ethylsulfanyl-thiazol-4-one and Piperidine-4-carboxylic acid following general procedure C.

Sources & evidence

ORD record
ord-889fb3087e914fad80fc94388c2891a8
Source dataset
uspto-grants-2012_09
Patent number
US08263781B2

Reaction notes

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