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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2384794Generated: November 1, 2026

Trifluoroacetic acid → rel-(2R,6S)-4-(3-Azetidinyl)-2,6-dimethylmorpholine

https://huagongshe.com/reaction/2384794

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 67239383HCID 67239383—
Productrel-(2R,6S)-4-(3-Azetidinyl)-2,6-dimethylmorpholineHCID 66592027—

Reaction Steps

4-Azetidin-3-yl-2,6-(cis)-dimethyl-morpholine was prepared as a TFA salt from 3-(2,6-(cis)-Dimethyl-morpholin-4-yl)-azetidine-1-carboxylic acid tert-butyl ester following General Procedure H.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08263781B2
Source datasetuspto-grants-2012_09
ORD IDord-faff690c59b44189b93a4d6d908db2ed
Source noteuspto-grants-2012_09