(2S)-N-(1,1-Dimethylethyl)piperazine-2-carboxamide → 4-[5-({1-[2,4-Bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]-N-tert-butylpiperazine-2-(S)-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	(2S)-N-(1,1-Dimethylethyl)piperazine-2-carboxamide	HCID 9806153	—
Reactant	5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-ethylsulfanyl-thiazol-4-one	HCID 86654540	—
Product	4-[5-({1-[2,4-Bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]-N-tert-butylpiperazine-2-(S)-carboxamide	HCID 86674125	—

Reaction Steps

4-[5-({1-[2,4-Bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]-N-tert-butylpiperazine-2-(S)-carboxamide was prepared from 5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-ethylsulfanyl-thiazol-4-one and piperazine-2-(S)-carboxylic acid tert-butylamide following General Procedure C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08263781B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-b0295972485245ce95b1e297a2d27373
Source note	uspto-grants-2012_09