1-(Cyclopropylmethyl)piperazine → HCID 67240293, compound

HRID 2384815Notes

Reaction equation

HRID 2384815 reaction equation
[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20](SCC)=[N:19][C:18]4=[O:25])=[CH:13][CH:14]=3)[C:9]([C:26]#[N:27])=[N:8]2)=[C:4]([C:30]([F:33])([F:32])[F:31])[CH:3]=1.[CH:34]1([CH2:37][N:38]2[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]2)[CH2:36][CH2:35]1>>[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20]([N:41]5[CH2:42][CH2:43][N:38]([CH2:37][CH:34]6[CH2:36][CH2:35]6)[CH2:39][CH2:40]5)=[N:19][C:18]4=[O:25])=[CH:13][CH:14]=3)[C:9]([C:26]#[N:27])=[N:8]2)=[C:4]([C:30]([F:32])([F:31])[F:33])[CH:3]=1

Participants

3

Reactant 2

HCID 9658751-(Cyclopropylmethyl)piperazineHCID 67240440HCID 67240440, compound

Product 1

HCID 67240293HCID 67240293, compound

Procedure

1-[4-Chloro-2-(trifluoromethyl)benzyl]-5-({2-[4-(cyclopropylmethyl)piperazin-1-yl]-4-oxo-1,3-thiazol-5(4H)-ylidene}methyl)-1H-indazole-3-carbonitrile was prepared from 1-(4-Chloro-2-trifluoromethyl-benzyl)-5-(2-ethylsulfanyl-4-oxo-4H-thiazol-5-ylidenemethyl)-1H-indazole-3-carbonitrile and 1-Cyclopropylmethyl-piperazine following General Procedure C.

Sources & evidence

ORD record
ord-cac7fd85a43543e38df22d68aa12b26d
Source dataset
uspto-grants-2012_09
Patent number
US08263781B2

Reaction notes

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