(2R)-piperazine-2-carboxylic acid methylamide → (2R)-4-[5-({1-[2,4-Bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]-N-methylpiperazine-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	(2R)-piperazine-2-carboxylic acid methylamide	HCID 67240742	—
Reactant	5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-ethylsulfanyl-thiazol-4-one	HCID 86654540	—
Product	(2R)-4-[5-({1-[2,4-Bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]-N-methylpiperazine-2-carboxamide	HCID 86654615	—

Reaction Steps

(2R)-4-[5-({1-[2,4-Bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]-N-methylpiperazine-2-carboxamide was prepared from 5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-ethylsulfanyl-thiazol-4-one and (2R)-piperazine-2-carboxylic acid methylamide following General Procedure C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08263781B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-f19a8243f43a4404b1fbd07a03832b14
Source note	uspto-grants-2012_09