HRID2384858

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID61739075

未命名化合物

结构：CCCSC1=NC(=O)C(=Cc2ccc3c(cnn3Cc3ccc(C(F)(F)F)cc3C(F)(F)F)c2)S1

HCID86654589

未命名化合物

PRODUCTS

生成物

结构：COC(=O)CNC(=O)[C@@H]1CN(C2=NC(=O)C(=Cc3ccc4c(cnn4Cc4ccc(C(F)(F)F)cc4C(F)(F)F)c3)S2)CCO1

HCID86654629

未命名化合物

PROCEDURE

实验过程

Methyl N—({(2S)-4-[5-({1-[2,4-bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]morpholin-2-yl}carbonyl)glycinate was prepared from 5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-propylsulfanyl-thiazol-4-one and [(Morpholine-2-carbonyl)-amino]-acetic acid methyl ester following General Procedure B.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-db96847dedfd40deb4e95546241e2282
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08263781B2
来源说明: uspto-grants-2012_09

反应 SMILES

[F:1][C:2]([F:35])([F:34])[C:3]1[CH:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[CH:26][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=[C:16]3[S:20][C:19](SCCC)=[N:18][C:17]3=[O:25])=[CH:12][CH:13]=2)[CH:8]=[N:7]1.[CH3:36][O:37][C:38](=[O:49])[CH2:39][NH:40][C:41]([CH:43]1[O:48][CH2:47][CH2:46][NH:45][CH2:44]1)=[O:42]>>[F:35][C:2]([F:1])([F:34])[C:3]1[CH:29]=[C:28]([C:30]([F:33])([F:31])[F:32])[CH:27]=[CH:26][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=[C:16]3[S:20][C:19]([N:45]4[CH2:46][CH2:47][O:48][C@H:43]([C:41]([NH:40][CH2:39][C:38]([O:37][CH3:36])=[O:49])=[O:42])[CH2:44]4)=[N:18][C:17]3=[O:25])=[CH:12][CH:13]=2)[CH:8]=[N:7]1