Sodium Hydroxide → HCID 68953118, compound

Participants

Reaction Steps

Suspend 4-[2-(4-chloro-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-2-methoxy-benzoic acid methyl ester (0.4 g, 0.94 mmol) in methanol (5 mL) and tetrahydrofuran (5 mL) and add 1 N NaOH (1.13 mL, 1.13 mmol). Heat the mixture at reflux for 16 h, cool to RT, and concentrate in vacuo. Suspend the residue in water (25 mL) and acidify with 10% sodium bisulfate. Extract the mixture with ethyl acetate (4×20 mL) to give a suspension in the organic portion. Filter the solid and dry in vacuo to give 0.19 g (49%) of the title compound. Concentrate the filtrate in vacuo to give 0.09 g (23%) more of the title compound. MS/ES m/z (35Cl) 414.0 [M+H]+.

Provenance & Evidence