Triethylamine → HCID 86629209, compound

Participants

Reaction Steps

Dissolve 2-(4-chloro-phenyl)-6-[4-((R)-3-hydroxy-pyrrolidin-1-yl)-3-methoxy-phenyl]-6H-thieno[2,3-c]pyridin-7-one (2.407 g, 5.34 mmol) in CH2Cl2 (50 mL) and add MsCl (0.46 mL, 5.87 mmol) and Et3N (1.0 mL, 7.32 mmol). Stir the mixture at RT for one hour. Dilute the mixture with CH2Cl2 (50 mL) and wash with water (30 mL). Dry the solution with Na2SO4, filter, and concentrate. Purify the crude material by chromatography, eluting with 10% EtOAc/CH2Cl2 to give 1.05 g (37%) of the title compound. LC-MS/ES m/z (35Cl) 531.8 [M+H]+.

Provenance & Evidence