HCID 68950273, compound → (R)-5-(hydroxymethyl)-4-methylmorpholin-3-one

Participants

Reaction Steps

Prepare a slurry containing 10% Pd/C (137 mg) in MeOH (50 mL). Add a solution of (R)-5-benzyloxymethyl-4-methyl-morpholin-3-one (1.3 g, 5.5 mmol) in MeOH (100 mL). Pressurize with hydrogen gas (50 psi) and stir for 2 h. Filter the reaction through Celite® and elute with MeOH. Concentrate the filtrate to give 767 mg (96%) of the title compound. MS/ES m/z 146.1 [M+H]+.

Provenance & Evidence