Trifluoroacetic acid → HCID 86629212, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve 3-(4-bromo-2-methoxy-phenoxy)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester (603 mg, 1.55 mmol) in dichloromethane (10 mL) and cool the mixture to 0° C. Add trifluoroacetic acid (2.0 mL, 26.45 mmol) and warm the mixture to room temperature for one hour. Remove the volatiles via reduced pressure and then apply to two 10 g SCX cartridges. Wash the material with methanol then elute the material with 2N ammonia in methanol to give 420 mg (93%) of the title compound as a clear oil. LC-MS/ES m/z (81Br) 290.0 [M+H]+.

Provenance & Evidence