(Diethylamino)sulfur trifluoride → HCID 86629214, compound

Participants

Reaction Steps

Add diethylaminosulfur trifluoride (0.173 mL, 1.31 mmol) to a solution of 4-(4-bromo-2-methoxy-phenoxy)-1-methyl-pyrrolidin-3-ol (0.329 g, 1.09 mmol) in dichloromethane (7 mL) at −78° C. Warm the mixture to room temperature and stir overnight. Evaporate the mixture and purify the resulting residue by silica gel chromatography, eluting with 0-70% ethyl acetate/hexane to give 130 mg (39%) of the title compound as a light brown oil. LC-MS/ES m/z (81Br) 306.0 [M+H]+.

Provenance & Evidence