HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2384941Generated: November 1, 2026
Potassium Carbonate → N-(4-bromophenyl)-2-(pyrrolidin-1-yl)acetamide
https://huagongshe.com/reaction/2384941
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-(4-Bromophenyl)-2-chloroacetamide | HCID 17374 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(4-bromophenyl)-2-(pyrrolidin-1-yl)acetamide | HCID 1091709 | 99.5% |
Reaction Steps
Add potassium carbonate (2.1 g, 15.5 mmol) and pyrrolidine (9.65 mL, 116 mmol) to a solution of N-(4-bromophenyl)-2-chloroacetamide (2.0 g, 7.7 mmol) in acetonitrile (78 mL) at RT. Heat the mixture at 80° C. for 4 h. Cool the mixture to RT, dilute with CH2Cl2, and wash with brine and water. Dry the organic layer over Na2SO4, filter, and concentrate to give 2.17 g (99%) of the title compound. LC-ES/MS m/z (79Br) 283.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08263772B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-329036b9e1724bee98bc66b081f553f9 |
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| Source note | uspto-grants-2012_09 |
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