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4-Chloroisatin → 1-(diphenylmethyl)-6-fluoro-1H-indole-2,3-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloroisatin | HCID 96047 | — |
| 反応物 | 6-Fluoroisatin | HCID 373905 | — |
| 生成物 | 1-(diphenylmethyl)-6-fluoro-1H-indole-2,3-dione | HCID 67357812 | — |
反応手順
Following the procedure as described in PREPARATION 4A, and making non-critical variations using 6-fluoroisatin (Sadler, P. W., J. Org. Chem. (1956), 21(2):169-70) to replace 4-chloroisatin, 1-(diphenylmethyl)-6-fluoro-1H-indole-2,3-dione was obtained (76%): mp 167-169° C. (diethyl ether); 1H NMR (300 MHz, DMSO-d6) 7.41-7.27 (m, 11H), 6.77 (s, 1H), 6.30-6.26 (m, 1H), 5.82-5.80 (m, 1H); MS (ES+) m/z 354.1 (M+23).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08263606B2 |
| 出典データセット | uspto-grants-2012_09 |
| ORD ID | ord-c46fb4f644c247288cf4c43551f093a3 |
| 出典メモ | uspto-grants-2012_09 |