4-chloro-1-(diphenylmethyl)-3-hydroxy-3-(6-hydroxy-2,3-dihydro-1-benzofuran-5-yl)-1,3-dihydro-2H-indol-2-one → HCID 68599064, compound

HRID 2384997Notes

Reaction equation

HRID 2384997 reaction equation
[C:1]1([CH:7]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[N:8]2[C:16]3[C:11](=[C:12]([F:18])[CH:13]=[CH:14][C:15]=3[CH3:17])[C:10](O)([C:19]3[C:20]([OH:28])=[CH:21][C:22]4[O:26][CH2:25][CH2:24][C:23]=4[CH:27]=3)[C:9]2=[O:30])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.ClC1C=CC=C2C=1C(O)(C1C(O)=CC3OCCC=3C=1)C(=O)N2C(C1C=CC=CC=1)C1C=CC=CC=1>>[C:31]1([CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[N:8]2[C:16]3[C:11](=[C:12]([F:18])[CH:13]=[CH:14][C:15]=3[CH3:17])[CH:10]([C:19]3[C:20]([OH:28])=[CH:21][C:22]4[O:26][CH2:25][CH2:24][C:23]=4[CH:27]=3)[C:9]2=[O:30])[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1

Participants

3

Reactant 2

HCID 673567944-chloro-1-(diphenylmethyl)-3-hydroxy-3-(6-hydroxy-2,3-dihydro-1-benzofuran-5-yl)-1,3-dihydro-2H-indol-2-oneHCID 68596899HCID 68596899, compound

Product 1

HCID 68599064HCID 68599064, compound

Procedure

Following the procedure as described in PREPARATION 4C, and making non-critical variations using 1-(diphenylmethyl)-4-fluoro-3-hydroxy-3-(6-hydroxy-2,3-dihydro-1-benzofuran-5-yl)-7-methyl-1,3-dihydro-2H-indol-2-one to replace 4-chloro-1-(diphenylmethyl)-3-hydroxy-3-(6-hydroxy-2,3-dihydro-1-benzofuran-5-yl)-1,3-dihydro-2H-indol-2-one, 1-(diphenylmethyl)-4-fluoro-3-(6-hydroxy-2,3-dihydro-1-benzofuran-5-yl)-7-methyl-1,3-dihydro-2H-indol-2-one was obtained (61%) as a colorless solid: MS (ES+) m/z 465.7 (M+1).

Sources & evidence

ORD record
ord-f2b44b5f878045fe97ee5d6831f7bd7b
Source dataset
uspto-grants-2012_09
Patent number
US08263606B2

Reaction notes

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