HCID 21959544, compound → HCID 21049551, compound

HRID 238510Notes

Reaction equation

HRID 238510 reaction equation
[CH3:1][C:2]1([CH3:21])[C:10]2[C:5](=[CH:6][C:7]([N+:11]([O-])=O)=[CH:8][CH:9]=2)[N:4]([CH:14]2[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]2)[CH2:3]1>CO>[CH3:1][C:2]1([CH3:21])[C:10]2[C:5](=[CH:6][C:7]([NH2:11])=[CH:8][CH:9]=2)[N:4]([CH:14]2[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]2)[CH2:3]1

Participants

3

Reactant 1

HCID 21959544HCID 21959544, compound

Product 1

HCID 21049551HCID 21049551, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3,3-Dimethyl-1-(1-methyl-piperidin-4-yl)-6-nitro-2,3-dihydro-1H-indole (600 mg, Step E) was dissolved in MeOH (20 mL), the mixture was bubbled with H2 for 10 min. 10% Pd/C (100 mg) was added and the mixture was stirred under H2 overnight. The mixture was filtered through Celite® and concentrated in vacuo to afford the title compound as an oil. MS: 260 (M+1). Calc'd. for C16H25N3—259.39.

Workup

  1. customthe mixture was bubbled with H2 for 10 min
  2. addition10% Pd/C (100 mg) was added
  3. filtrationThe mixture was filtered through Celite®
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-7f630b41bc6d4ad6b87796493a8c3a0d
Source dataset
uspto-grants-2014_02
Patent number
US08642624B2

Reaction notes

Loading…